Ralph Brinster

National Medal of Science

Biological Sciences

For his fundamental contributions to the development and use of transgenic mice. His research has provided experimental foundations and inspiration for progress in germline genetic modification in a range of species, which has generated a revolution in biology, medicine, and agriculture.

For his fundamental contributions to the development and use of transgenic mice. His research has provided experimental foundations and inspiration for progress in germline genetic modification in a range of species, which has generated a revolution in biology, medicine, and agriculture.

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Birth
March 10, 1932
Age Awarded
78
Country of Birth
USA
Key Contributions
Germ Treatment
Awarded by
Barack Obama
Education
University of Pennsylvania
Rutgers University
Areas of Impact
Health & Medicine
Affiliations
University of Pennsylvania
I

It was the scientific journal cover seen around the world: an average size mouse being dwarfed by this super-sized sibling. Picked up by newspapers from New York to Hong Kong in 1982, the image was seen by millions.

Why? Those mice represented the groundbreaking genetic work of veterinarian Ralph Brinster—proof that it was possible to transfer a gene from one animal into the embryo of another in a way that ensured the gene was not only expressed in the first animal, but in its offspring as well. This work, known as transgenics, has the potential to change fields as diverse as cancer treatment and the production of food crops.

Growing up on a farm, Brinster had ample opportunities to see firsthand how important breeding was and how it passed along characteristics from one generation of animal to the next. Germ lines, a technical name for sex cells like eggs and sperm, are the way that sexually reproducing creatures pass on their genes. In Brinster’s own words, “they are the only cells that biology really cares about.”

Brinster was the first to develop a way to observe and manipulate these cells and the embryos that result from them outside the body. The method he developed, still widely used today, allowed him to understand more about germ line cells and embryo development—and how alterations of those cells might be possible.

From there, he and collaborator Walter Palmiter went on to refine their revolutionary method of creating transgenic creatures that were able to pass their modified genes on to their offspring. Their creation of a transgenic mouse not only made Brinster the first veterinarian to win a National Medal of Science, but shined a light on how we might one day be able to use genetic therapies to treat a range of disorders like cystic fibrosis and cancer.

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