Elizabeth F. Neufeld

National Medal of Science

Biological Sciences

For her contributions to the understanding of the lysosomal storage diseases, demonstrating the strong linkage between basic and applied scientific investigation.

For her contributions to the understanding of the lysosomal storage diseases, demonstrating the strong linkage between basic and applied scientific investigation.

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Birth
September 27, 1928
Age Awarded
66
Country of Birth
France
Key Contributions
Research On Genetic Diseases
Awarded by
Bill Clinton
Education
University of California, Berkeley
Queens College
Areas of Impact
Health & Medicine
Affiliations
University of California, Los Angeles School of Medicine
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Elizabeth F. Neufeld first became interested in science while a high school student, her interest sparked by her biology teacher. She went on to receive a Ph.D. in biochemistry in 1956, a time where women mostly did not choose careers in scientific research. "Some people looked at women who wanted a career in science as a little eccentric," Neufeld was quoted in an interview, "but I enjoyed what I was doing and I decided I would persevere."

Neufeld took a position with the National Institutes of Health, and it’s there she made a groundbreaking discovery researching mucopolysaccharidoses (MPS), disorders, such as Hurler syndrome, in which MPS (a complex series of sugars) cannot be stored or metabolized properly. The disorders can cause stunted physical and mental growth, vision and hearing problems, and a short life span.

Her research showed that the defects in Hurler syndrome was due to decreased degradation of MPS and their resulting accumulation in lysosomes rather than an overproduction of the sugars. Her research opened the door for prenatal diagnosis of MPS disorders. 

By Jen Santisi

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